Yesterday, I started on the open label for LMTX, which the article below says had a 90% success rate in stopping the progression in its Phase 2 trials. I just completed the 18-month Phase 3 trial four weeks ago, and yes, while I still have limitations, I (and my neurologist) can attest that things have not gotten worse.
I am SO very grateful to Professor Claude Wischik, MD, PhD and everyone at TauRx and the San Francisco Clinical Research Center.
First Evidence of Potential Efficacy of Tau Aggregation Inhibitor Therapy in Alzheimer’s Disease
megan, very happy to hear. we should be pushing for LMTX for all AD patients as soon as possible! I can't stand to see my grandma's decline..
ReplyDeleteThank you, and yes, I would hope this gets fast-tracked through the FDA as soon as the Phase 3 trial completes. I am so sorry about your grandma and hope you and your family are getting the support and love you need to help her.
DeleteI am so glad for you Megan. Not to have declined during the 18-month TauRx trial is wonderful! I really hope LMTX can be made available to everyone soon. There are just SO many AD people in the world that need it.
ReplyDeleteRegards. JK
Thanks so much, JK. Yes, I hope it gets fast tracked as soon as the Phase 3 trial results are avialable!
DeleteMegan, that is fantastic. Like so many others, I have been waiting for this day since I read my first article on TauRx back in april 2009. My only concern now is that this drug is effective for all types of Alzheimers especially early onset with gene mutations. Not intending to sound self centered - I have seen three generations go through this disease that has taken a great deal of my family and I want to see it end. May you continue to have success. Thinking of all those that desperately need this drug
ReplyDeleteM..
Thank you M. I would hope that anyone with a family history of AD -- even though they may not have symptoms (yet) -- would be offered this when it becomes available...at a price all can afford!
DeleteMy husband did not qualify for the TauRx trial. I am so happy for your progress (or lack of deterioration). I was wondering if your study site is giving you any indication of how long they anticipate the actual drug making it onto the market. I know it was given orphan drug status as it relates to frontal lobe dementia; but my understanding is that they had not completed enrollment for that treatment "niche". I was also wondering if you do the posting on your blogs or if someone assists you; if you are doing your own posting and this medication has allowed you to maintain this level of functionality, you are indeed blessed. I was also wondering if you are aware of the dosage you are currently taking of the study med; and, on a less serious note, how do you get rid of the blue stains from the methylene blue? I wish you continued progress.
ReplyDeleteThank you for your kind comments. I believe the Phase 3 trial results will be published next year, and then fast-tracked through the FDA (2 years or less). The latest from Mayo Clinic showing tau protein as the culprit may make the approval process go faster, I hope.
DeleteI am able to post on the blog, first using Word for spell and grammar check. It takes me much longer to compose thoughts into words into computah input these days, but it's well worth the effort.
I am on 100 mg tablets of LMTM - leuco-methylthionium bis(hydromethanesulfonate).
Less seriously -- soaking undies in water with some ascorbic acid, dapple painting my toilet seat blue/green, and constant cleaning of the toilet bowl!
Megan, I am very happy for you. A few days ago I got in touch with TauRx and got a hint that the drug might hit the markets during the second half 2017. Obviously it all depends on the phase 3 trial outcome and how much time it will take to clear the FDA approval.
ReplyDeleteI sincerely hope even the other patients from the clinic you are enrolled at have positive experience to share. You have any information to share with us on this?
Wishing you a continued success.
AJ